Biotechnology
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In vitro antioxidant mechanism of action of hibiscus sabdariffa in the induction of apoptosis against breast cancer
(Taylor and Francis Ltd., 2023)The antioxidant mechanism of action in the process of cytotoxicity, and pro-apoptotic activity of Hibiscus sabdariffa water extract (HSWE) was assessed against non-cancerous (MCF12A) and breast cancer (MCF7) cells grown ... -
Molecular and epidemiological analyses of sheeppox outbreaks in Russia from 2013 to 2021
(Wiley-Hindawi, 2023)Sheeppox (SPP) is a transboundary infectious disease that affects sheep and goats, leading to significant losses in countries with extensive small ruminant breeding programs. While sporadic SPP outbreaks have been observed ... -
Development and application of a real-time polymerase chain reaction assay to detect lumpy skin disease virus belonging to the Kenyan sheep and goat pox group
(BioMed Central Ltd, 2023)Lumpy skin disease (LSD) outbreaks in Southeast and South Asia are attributed to different lineages of LSD virus (LSDV). Variants belonging to the novel recombinant cluster 2.5 circulate in China and Thailand, while a ... -
Heterocyclic (pyrazine)carboxamide Ru(II) complexes: structural, experimental and theoretical studies of interactions with biomolecules and cytotoxicity
(Royal Society of Chemistry, 2024)Treatments of N-(1H-benzo[d]imidazol-2-yl)pyrazine-2-carboxamide (HL1) and N-(benzo[d]thiazol-2-yl)pyrazine-2-carboxamide carboxamide ligands (HL2) with [Ru(p-cymene)Cl2]2 and [Ru(PPh3)3Cl2] precursors afforded the respective ... -
Salinity induced leaf anatomical responses and chemical composition in tetragonia decumbens mill.: An underutilized edible halophyte in South Africa
(Pleiades Publishing, 2023)Abstract: Tetragonia decumbens Mill. has recently been reported to withstand the adverse effect of salinity. However, its leaf anatomical responses are poorly understood since previous studies were focused on basic ... -
Carbon monoxide alleviates salt-induced oxidative damage in sorghum bicolor by Inducing the expression of proline biosynthesis and antioxidant genes
(Multidisciplinary Digital Publishing Institute (MDPI), 2024)Crop growth and yield are affected by salinity, which causes oxidative damage to plant cells. Plants respond to salinity by maintaining cellular osmotic balance, regulating ion transport, and enhancing the expression of ... -
Methoxylated flavonols and ent-kaurane diterpenes from the south african helichrysum rutilans and their cosmetic potential
(MDPI [Commercial Publisher], 2023)Chromatographic fractionation of a methanol extract of Helichrysum rutilans afforded seven known compounds. The isolated compounds were identified as 5,7,8-trihydroxy-3,6-dimethoxyflavone-8-O-2-methyl-2-butanoate (C-1), ... -
Mitochondrial dysfunction and diabetes in South Africa: A review
(Elsevier B.V., 2024)Type 2 diabetes mellitus (T2DM) is a growing public health concern globally, and more so in developing countries like South Africa where it is characterized by an alarmingly high prevalence. Emerging evidence suggests that ... -
Rewiring bacillus subtilis and bioprocess optimization for oxidoreductive reaction-mediated biosynthesis of d-tagatose
(Elsevier Ltd, 2023)D-tagatose holds significant importance as a functional monosaccharide with diverse applications in food, medicine, and other fields. This study aimed to explore the oxidoreductive pathway for D-tagatose production, ... -
Anticancer, antioxidant, and catalytic activities of green synthesized gold nanoparticles using avocado seed aqueous extract
(American Chemical Society, 2023)Disposal of agricultural waste has a negative impact on the environment and human health and may contribute to the greenhouse effect. The field of nanotechnology could provide alternative solutions to upcycle agricultural ... -
Thioglycolic acid-capped gold nanoparticle/cytochrome p450-2e1 electrochemical biosensor for isoniazid
(Elsevier B.V., 2023)Tuberculosis (TB) is one of the deadliest diseases in Africa and it is classified as a serious global health problem. A new threat associated with the disease is the emergence of multidrug-resistant TB (MDR-TB), which ... -
Methoxylated Flavonols and ent-Kaurane Diterpenes from the South African Helichrysum rutilans and Their Cosmetic Potential
(Multidisciplinary Digital Publishing Institute (MDPI, 2023)Abstract: Chromatographic fractionation of a methanol extract of Helichrysum rutilans afforded seven known compounds. The isolated compounds were identified as 5,7,8-trihydroxy-3,6-dimethoxyflavone8-O-2-methyl-2-butanoate ... -
Plant biomarkers as early detection tools in stress management in food crops: a review
(Springer Science and Business Media Deutschland GmbH, 2024)Main conclusion: Plant Biomarkers are objective indicators of a plant’s cellular state in response to abiotic and biotic stress factors. They can be explored in crop breeding and engineering to produce stress-tolerant crop ... -
Genetic preservation of SLC22A3 in the Admixed and Xhosa populations living in the Western Cape
(Springer Science and Business Media B.V., 2023)Background Amphiphilic solute facilitator organic cation transporters mediate the movement of various endogenous and exogenous organic cations, including crucial drugs like metformin, oxaliplatin, and lamivudine. These ... -
Phytonanotherapy for the treatment of metabolic dysfunction-associated steatotic liver disease
(Multidisciplinary Digital Publishing Institute (MDPI), 2024)Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as nonalcoholic fatty liver disease, is a steatotic liver disease associated with metabolic syndrome (MetS), especially obesity, hypertension, ... -
Mechanistic insight into the anti-alternaria activity of bimetallic zinc oxide and silver/zinc oxide nanoparticles
(Elsevier Ltd, 2024)Alternaria alternata is an opportunistic phytopathogen that negatively impact the growth and production of a wide variety of host plants. In this study, we evaluated the antifungal potential of biogenic ZnO, and ... -
The cytotoxicity of cotyledon orbiculata aqueous extract and the biogenic silver nanoparticles derived from the extract
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)Green synthesized silver nanoparticles (AgNPs) have become popular because of their promising biological activities. However, for most of these nanoparticles, the cytotoxic effects have not been determined and their safety ... -
Use of the mcherry fluorescent protein to optimize the expression of class I lanthipeptides in escherichia coli
(BioMed Central Ltd, 2023)Background: Lanthipeptides are a rapidly expanding family of ribosomally synthesized and post-translationally modified natural compounds with diverse biological functions. Lanthipeptide structural and biosynthetic genes ... -
Open Institute of the African BioGenome Project: Bridging the gap in African biodiversity genomics and bioinformatics
(Nature Research, 2023)Africa, a continent of 1.3 billion people, had 326 researchers per one million people in 2018 (Schneegans, 2021; UNESCO, 2022), despite the global average for the number of researchers per million people being 1368 ... -
Seed priming with MeJa prevents salt-induced growth inhibition and oxidative damage in sorghum bicolor by inducing the expression of jasmonic acid biosynthesis genes
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)Salinity is one of the major detrimental abiotic stresses at the forefront of deterring crop productivity globally. Although the exogenous application of phytohormones has formerly proven efficacious to plants, their effect ...
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