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Cross-sectional study of prevalence and determinants of uncontrolled hypertension among South African adult residents of Mkhondo municipality
(Springer Nature, 2020)
Achieving the blood pressure treatment target in individuals with hypertension is a serious global health challenge. Furthermore, the actual burden of uncontrolled hypertension is poorly understood, especially in the ...
Cross-sectional study of the association of 5 single nucleotide polymorphisms with enalapril treatment response among South African adults with hypertension
(NLM (Medline), 2021-11-19)
This study investigates the association of 5 single nucleotide polymorphisms (SNPs) in selected genes (ABO, VEGFA, BDKRB2, NOS3, and ADRB2) with blood pressure (BP) response to enalapril. The study further assessed genetic ...
Genetic association of solute carrier transporter gene variants with metformin response
(Balkan Journal of Medical Genetics, 2021)
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by elevated blood glucose levels and is influenced by both genetic and environmental factors. It is treated with various classes of oral antidiabetic ...
Genomic association of single nucleotide polymorphisms with blood pressure response to hydrochlorothiazide among south african adults with hypertension
(MDPI, 2020)
: This study described single nucleotide polymorphisms (SNPs) in hydrochlorothiazideassociated genes and further assessed their correlation with blood pressure control among South
African adults living with hypertension. ...
The potential of chalcone-capped gold nanoparticles for the management of diabetes mellitus
(Surfaces and Interfaces, 2021-08)
Searching for new natural bioactive capping agents represent an urgent priority in the green synthesis of metal nanoparticles. Additionaly, the biosaftey of metal nanparticles is a major concern especially in medical ...
Factors associated with glycemic control among South African adult residents of Mkhondo municipality living with diabetes mellitus
(Lippincott, Williams & Wilkins, 2020)
This study examines the rate and the influencing factors of glycemic control among adult residents living with DM in Mkhondo
Municipality of South Africa.
In this cross-sectional study, 157 individuals attending care for ...
Genetic polymorphisms and haplotypes of the organic cation transporter 1 gene (SLC22A1) in the Xhosa population of South Africa
(Brazilian Society of Genetics, 2014)
Human organic cation transporter 1 is primarily expressed in hepatocytes and mediates the electrogenic transport of
various endogenous and exogenous compounds, including clinically important drugs. Genetic polymorphisms ...
Genetic preservation of SLC22A3 in the Admixed and Xhosa populations living in the Western Cape
(Springer Science and Business Media B.V., 2023)
Background Amphiphilic solute facilitator organic cation transporters mediate the movement of various endogenous and
exogenous organic cations, including crucial drugs like metformin, oxaliplatin, and lamivudine. These ...
Mitochondrial dysfunction and diabetes in South Africa: A review
(Elsevier B.V., 2024)
Type 2 diabetes mellitus (T2DM) is a growing public health concern globally, and more so in developing countries like South Africa where it is characterized by an alarmingly high prevalence. Emerging evidence suggests that ...