Biotechnology: Recent submissions
Now showing items 101-120 of 219
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Methylenetetrahydrofolate Reductase Polymorphism (rs1801133) and the Risk of Hypertension among African Populations: A Narrative Synthesis of Literature
(MDPI, 2022)In this review, we have gathered and analyzed the available genetic evidence on the association between the methylenetetrahydrofolate reductase gene (MTHFR), rs1801133 and the risk of Hypertension (HTN) in African ... -
Morpho-physiological, biochemical, and genetic responses to salinity in medicago truncatula
(MDPI, 2021)We used an integrated morpho-physiological, biochemical, and genetic approach to investigate the salt responses of four lines (TN1.11, TN6.18, JA17, and A10) of Medicago truncatula. Results showed that TN1.11 exhibited a ... -
Gene expression modulation of apoptotic and oestrogen receptor alpha genes by active fractions of selected Nigerian plants on cervical cancer cell line (hela)
(University of Benin, 2021)The roles of natural product in drug discovery and development cannot be over emphasised. It plays a vital role in human therapy and gives a better understanding on the cellular pathways.This study investigated the ... -
Isolation and characterization of lytic proteus virus 309
(MDPI, 2022)Proteus mirabilis is frequently associated with complicated urinary tract infections (UTIs) and is the main cause of catheter-associated urinary tract infections (CAUTIs). Treatment of such infections is complicated and ... -
Effect of copper sulphate and cadmium chloride on non-human primate sperm function in vitro
(MDPI, 2021)Abstract: In order to address the large percentage of unexplained male infertility in humans, more detailed investigations using sperm functional tests are needed to identify possible causes for compromised fertility. Since ... -
Factors associated with glycemic control among South African adult residents of Mkhondo municipality living with diabetes mellitus
(Lippincott, Williams & Wilkins, 2020)This study examines the rate and the influencing factors of glycemic control among adult residents living with DM in Mkhondo Municipality of South Africa. In this cross-sectional study, 157 individuals attending care for ... -
Biological synthesis of gold and silver nanoparticles using leaf extracts of Crassocephalum rubens and their comparative in vitro antioxidant activities
(Elsevier, 2020)The use of plant and plant products in the synthesis of silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs) is made possible because of the natural inherent phytochemicals responsible for the reduction of respective ... -
Phenolic content, antioxidant, cytotoxic and antiproliferative effects of fractions of Vigna subterraenea (L.) verdc from Mpumalanga, South Africa
(Elsevier, 2021)Consistent intake of legumes has been correlated with decreased possibility of developing colorectal cancer (CRC) due to the content of some phytochemicals like polyphenols. Bambara groundnut (BGN) is an underutilized ... -
Inhibitory potential of repurposed drugs against the SARS-CoV-2 main protease: A computational-aided approach
(Taylor and Francis, 2020)The exponential increase in cases and mortality of coronavirus disease (COVID-19) has called for a need to develop drugs to treat this infection. Using in silico and molecular docking approaches, this study investigated ... -
Three Novel Bacteria Associated with Two Centric Diatom Species from the Mediterranean Sea, Thalassiosira rotula and Skeletonema marinoi
(MDPI, 2021)Diatoms are a successful group of microalgae at the base of the marine food web. For hundreds of millions of years, they have shared common habitats with bacteria, which favored the onset of interactions at different ... -
Cross-sectional study of the association of 5 single nucleotide polymorphisms with enalapril treatment response among South African adults with hypertension
(NLM (Medline), 2021-11-19)This study investigates the association of 5 single nucleotide polymorphisms (SNPs) in selected genes (ABO, VEGFA, BDKRB2, NOS3, and ADRB2) with blood pressure (BP) response to enalapril. The study further assessed genetic ... -
Multifunctional Gold Nanoparticles for Improved Diagnostic and Therapeutic Applications: A Review
(Springer Open, 2021)The medical properties of metals have been explored for centuries in traditional medicine for the treatment of infections and diseases and still practiced to date. Platinum-based drugs are the first class of metal-based ... -
Isolation and characterization of strain exiguobacterium sp. Krl4, a producer of bioactive secondary metabolites from a Tibetan glacier
(MPDI, 2021)Extremophilic microorganisms represent a unique source of novel natural products. Among them, cold adapted bacteria and particularly alpine microorganisms are still underexplored. Here, we describe the isolation and ... -
Three novel bacteria associated with two centric diatom species from the Mediterranean Sea, Thalassiosira rotula and Skeletonema marinoi
(MPDI, 2021)Diatoms are a successful group of microalgae at the base of the marine food web. For hundreds of millions of years, they have shared common habitats with bacteria, which favored the onset of interactions at different ... -
Assessment of genetic diversity in Tunisian populations of Medicago polymorpha based on SSR markers
(Instituto de Investigaciones Agropecuarias, 2021)Medicago polymorpha L. is a herbaceous legume that can be a useful pasture crop, especially in Mediterranean climates. This study aimed to analyze the genetic variation in five populations of M. polymorpha collected from ... -
Nanotechnology-based strategies for effective and rapid detection of sars-cov-2
(MDPI, 2021)The coronavirus disease 2019 (COVID-19) pandemic has gained worldwide attention and has prompted the development of innovative diagnostics, therapeutics, and vaccines to mitigate the pandemic. Diagnostic methods based ... -
Progesterone, myo-inositol, dopamine and prolactin present in follicular fluid have differential effects on sperm motility subpopulations
(MDPI, 2021)Considering the challenges surrounding causative factors in male infertility, rather than relying on standard semen analysis, the assessment of sperm subpopulations and functional characteristics essential for fertilization ... -
The Role of Cytoskeletal Proteins in the Formation of a Functional In Vitro Blood-Brain Barrier Model
(MDPI, 2022)The brain capillary endothelium is highly regulatory, maintaining the chemical stability of the brain’s microenvironment. The role of cytoskeletal proteins in tethering nanotubules (TENTs) during barrier-genesis was ... -
In vitro evaluation of the anti-diabetic potential of aqueous acetone Helichrysum petiolare extract (AAHPE) with molecular docking relevance in diabetes mellitus
(MDPI, 2021-12)Diabetes mellitus (DM) is a chronic metabolic condition that can lead to significant complications and a high fatality rate worldwide. Efforts are ramping up to find and develop novel α-glucosidase and α-amylase inhibitors ... -
Characterization of a highly xylose tolerant β-xylosidase isolated from high temperature horse manure compost
(BMC, 2021): There is a continued need for improved enzymes for industry. β-xylosidases are enzymes employed in a variety of industries and although many wild-type and engineered variants have been described, enzymes that are highly ...