Biotechnology: Recent submissions
Now showing items 121-140 of 219
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Hypertension in African populations: Review and computational insights
(MPDI, 2021)Hypertension (HTN) is a persistent public health problem affecting approximately 1.3 billion individuals globally. Treatment-resistant hypertension (TRH) is defined as high blood pressure (BP) in a hypertensive patient ... -
Common bean as a potential crop for future food security: an overview of past, current and future contributions in genomics, transcriptomics, transgenics and proteomics
(Taylor & Francis Open Access, 2021)Common bean is an important legume crop having high quality protein, micronutrients, vitamins and antioxidants, which makes it a “grain of hope” for poor communities. Hence, a good number of breeding activities have been ... -
Stress modulation as a means to improve yeasts for lignocellulose bioconversion
(Springer, 2021)The second-generation (2G) fermentation environment for lignocellulose conversion presents unique challenges to the fermentative organism that do not necessarily exist in other industrial fermentations. While extreme ... -
Indigenous African cereal crops can contribute to mitigation of the impact of climate change on food security
(Arid land institute, 2021)Zea mays L. (maize) is one of the top three cultivated cereals globally, along with wheat and rice. The United States, China, and Brazil are among the largest producers of maize, producing approximately 79% of the world’s ... -
Antioxidant responses are associated with differences in drought tolerance between maize and sorghum
(Arid land institute, 2021)Drought is a major cause of decreased yield in crops worldwide. Sorghum (Sorghum bicolor) and maize (Zea mays) are two of the key crops in Africa serving as human food as well as livestock feed. For improved crop ... -
Evaluation of the morpho-physiological, biochemical and molecular responses of contrasting medicago truncatula lines under water deficit stress
(MPDI, 2021)Medicago truncatula is a forage crop of choice for farmers, and it is a model species for molecular research. The growth and development and subsequent yields are limited by water availability mainly in arid and semi-arid ... -
Role and merits of green based nanocarriers in cancer treatment
(MPDI, 2021)The use of nanocarriers for biomedical applications has been gaining interests from researchers worldwide for the delivery of therapeutics in a controlled manner. These “smart” vehicles enhance the dissolution and the ... -
Venom proteomic analysis of medically important Nigerian viper Echis ocellatus and Bitis arietans snake species
(Elsevier, 2021)Snakebite envenoming remains a neglected tropical disease which poses severe health hazard, especially for the rural inhabitants in Africa. In Nigeria, vipers are responsible for the highest number of deaths. Hydrophili ... -
The antimicrobial and anti-inflammatory effects of silver nanoparticles synthesised from cotyledon orbiculata aqueous extract
(MDPI, 2021)Cotyledon orbiculata, commonly known as pig’s ear, is an important medicinal plant of South Africa. It is used in traditional medicine to treat many ailments, including skin eruptions, abscesses, inflammation, boils and ... -
Evaluation of selected carotenoids of Lycopersicon esculentum variants as therapeutic targets for 'Alzheimer's disease: an in silico approach BMC Molecular and Cell Biology
(Springer, 2021-10)The seriousness and menace of the worldwide weight of 'Alzheimer's disease have been related to a few factors, which incorporate antioxidant system depletion, mutation of proteins, and high expression of cholinesterases ... -
The antimicrobial activity of biogenic silver nanoparticles synthesized from extracts of Red and Green European pear cultivars
(Taylor & Francis, 2021-01)Green nanotechnology stands amongst the leading giants of innovation for the twenty first century technological advances. More interesting, is the use of natural products as reducing agents. These could be recyclable ... -
Immunoinformatics design of a novel epitope-based vaccine candidate against dengue virus
(Springer, 2021-10)Dengue poses a global health threat, which will persist without therapeutic intervention. Immunity induced by exposure to one serotype does not confer long-term protection against secondary infection with other serotypes ... -
Genomic characterization of a prophage, Smhb1, that Infects Salinivibrio kushneri BNH isolated from a Namib Desert saline spring
(MDPI, 2021)Recent years have seen the classification and reclassification of many viruses related to the model enterobacterial phage P2. Here, we report the identification of a prophage (Smhb1) that infects Salinivibrio kushneri BNH ... -
In silico prediction of new antimicrobial peptides and proteins as druggable targets towards alternative anti-schistosomal therapy
(Elsevier, 2021)Schistosomiasis is a debilitating disease caused by a parasitic flatworm found in fresh- water. With the exponential increase in prevalence, Praziquantel (PZQ) remains the only effective treatment drug, however, resistance ... -
Synthesis, computational and biological studies of alkyltin(IV) N-methyl-N-hydroxyethyl dithiocarbamate complexes
(Elsevier, 2021)Methyltin(IV) of butyltin(IV)–N-hydroxyethyl dithiocarbamate complexes, represented as [(CH3)2Sn(L(OH))2] and [(C4H9)2Sn(L(OH))2] respectively were synthesized and characterized using spectroscopic techniques (1 H, 13C ... -
Green synthesis of metallic nanoparticles using some selected medicinal plants from southern africa and their biological applications
(MDPI, 2021)The application of metallic nanoparticles (MNPs), especially that of silver, gold, cobalt, and zinc as antimicrobial, anticancer, drug delivery, contrast, and bioimaging agents has transformed the field of medicine. Their ... -
Green synthesis of metallic nanoparticles using some selected medicinal plants from Southern Africa and their biological applications
(MPDI, 2021)The application of metallic nanoparticles (MNPs), especially that of silver, gold, cobalt, and zinc as antimicrobial, anticancer, drug delivery, contrast, and bioimaging agents has transformed the field of medicine. Their ... -
Bacterial viruses subcommittee and archaeal viruses subcommittee of the ictv: Update of taxonomy changes in 2021
(Springer, 2021)In this article, we – the Bacterial Viruses Subcommittee and the Archaeal Viruses Subcommittee of the International Committee on Taxonomy of Viruses (ICTV) – summarise the results of our activities for the period March ... -
Genetic association of solute carrier transporter gene variants with metformin response
(Balkan Journal of Medical Genetics, 2021)Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by elevated blood glucose levels and is influenced by both genetic and environmental factors. It is treated with various classes of oral antidiabetic ... -
Development of Effective Therapeutic Molecule from Natural Sources against Coronavirus Protease
(MDPI, 2021)Abstract: The SARS-CoV-2 main protease (Mpro) is one of the molecular targets for drug design. Effective vaccines have been identified as a long-term solution but the rate at which they are being administered is slow in ...