Browsing Research Articles (Biotechnology) by Issue Date
Now showing items 141-160 of 215
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Morpho-physiological, biochemical, and genetic responses to salinity in medicago truncatula
(MDPI, 2021)We used an integrated morpho-physiological, biochemical, and genetic approach to investigate the salt responses of four lines (TN1.11, TN6.18, JA17, and A10) of Medicago truncatula. Results showed that TN1.11 exhibited a ... -
Building HMM and molecular docking analysis for the sensitive detection of anti-viral pneumonia antimicrobial peptides (AMPs)
(Nature Research, 2021)Pneumonia is the main reason for mortality among children under five years, causing 1.6 million deaths every year; late research has exhibited that mortality is increasing in the elderly. A few biomarkers used for its ... -
Nanotechnology-based delivery systems for antimicrobial peptides
(MDPI, 2021)Antimicrobial resistance (AMR) is a significant threat to global health. The conventional antibiotic pool has been depleted, forcing the investigation of novel and alternative antimicrobial strategies. Antimicrobial peptides ... -
The antimicrobial activity of biogenic silver nanoparticles synthesized from extracts of Red and Green European pear cultivars
(Taylor & Francis, 2021-01)Green nanotechnology stands amongst the leading giants of innovation for the twenty first century technological advances. More interesting, is the use of natural products as reducing agents. These could be recyclable ... -
The Relationship between Cadmium Toxicity and the Modulation of Epigenetic Traits in Plants
(International Journal of Molecular Sciences, 2021-06)Elevated concentrations of heavy metals such as cadmium (Cd) have a negative impact on staple crop production due to their ability to elicit cytotoxic and genotoxic effects on plants. In order to understand the relationship ... -
PR-1-Like Protein as a Potential Target for the Identification of Fusarium oxysporum: An In Silico Approach
(BioTech, 2021-07)Fusarium oxysporum remains one of the leading causes of economic losses and poor crop yields; its detection is strained due to its presentation in various morphological and physiological forms. This research work sought ... -
The potential of chalcone-capped gold nanoparticles for the management of diabetes mellitus
(Surfaces and Interfaces, 2021-08)Searching for new natural bioactive capping agents represent an urgent priority in the green synthesis of metal nanoparticles. Additionaly, the biosaftey of metal nanparticles is a major concern especially in medical ... -
Immunoinformatics design of a novel epitope-based vaccine candidate against dengue virus
(Springer, 2021-10)Dengue poses a global health threat, which will persist without therapeutic intervention. Immunity induced by exposure to one serotype does not confer long-term protection against secondary infection with other serotypes ... -
Evaluation of selected carotenoids of Lycopersicon esculentum variants as therapeutic targets for 'Alzheimer's disease: an in silico approach BMC Molecular and Cell Biology
(Springer, 2021-10)The seriousness and menace of the worldwide weight of 'Alzheimer's disease have been related to a few factors, which incorporate antioxidant system depletion, mutation of proteins, and high expression of cholinesterases ... -
Cross-sectional study of the association of 5 single nucleotide polymorphisms with enalapril treatment response among South African adults with hypertension
(NLM (Medline), 2021-11-19)This study investigates the association of 5 single nucleotide polymorphisms (SNPs) in selected genes (ABO, VEGFA, BDKRB2, NOS3, and ADRB2) with blood pressure (BP) response to enalapril. The study further assessed genetic ... -
In vitro evaluation of the anti-diabetic potential of aqueous acetone Helichrysum petiolare extract (AAHPE) with molecular docking relevance in diabetes mellitus
(MDPI, 2021-12)Diabetes mellitus (DM) is a chronic metabolic condition that can lead to significant complications and a high fatality rate worldwide. Efforts are ramping up to find and develop novel α-glucosidase and α-amylase inhibitors ... -
The Role of Cytoskeletal Proteins in the Formation of a Functional In Vitro Blood-Brain Barrier Model
(MDPI, 2022)The brain capillary endothelium is highly regulatory, maintaining the chemical stability of the brain’s microenvironment. The role of cytoskeletal proteins in tethering nanotubules (TENTs) during barrier-genesis was ... -
Isolation and characterization of lytic proteus virus 309
(MDPI, 2022)Proteus mirabilis is frequently associated with complicated urinary tract infections (UTIs) and is the main cause of catheter-associated urinary tract infections (CAUTIs). Treatment of such infections is complicated and ... -
Methylenetetrahydrofolate Reductase Polymorphism (rs1801133) and the Risk of Hypertension among African Populations: A Narrative Synthesis of Literature
(MDPI, 2022)In this review, we have gathered and analyzed the available genetic evidence on the association between the methylenetetrahydrofolate reductase gene (MTHFR), rs1801133 and the risk of Hypertension (HTN) in African ... -
Green-synthesized zinc oxide nanoparticles mitigate salt stress in sorghum bicolor
(MDPI, 2022)Salinity is an abiotic stress that is responsible for more than 50% of crop losses worldwide. Current strategies to overcome salinity in agriculture are limited to the use of genetically modified crops and chemicals ... -
Fungal‑derived compounds and mycogenic nanoparticles with antimycobacterial activity: a review
(Springer, 2022)Tuberculosis (TB) is a persistent lung infection caused by Mycobacterium tuberculosis. The disease is characterized by high mortality rates of over 1 million per year. Unfortunately, the potency and efectiveness of currently ... -
The association of mthfr (rs1801133) with hypertension in an indigenous South African population
(Frontiers Media, 2022)The current study sought to investigate the association between the methylenetetrahydrofolate reductase (MTHFR) variant (rs1801133) and the risk of developing hypertension (HTN) in an indigenous South African population.A ... -
Prevalence, patterns and determinants of dyslipidaemia among South African adults with comorbidities
(Nature Research, 2022)The present study assessed the prevalence, patterns and determinants of dyslipidaemia among South African adults with multi-morbidities. In this study, 614 individuals with DM and hypertension were recruited. Dyslipidaemia ... -
Analytical studies of antimicrobial peptides as diagnostic biomarkers for the detection of bacterial and viral Pneumonia
(MDPI, 2022)Pneumonia remains one of the leading causes of infectious mortality and significant economic losses among our growing population. The lack of specific biomarkers for correct and timely diagnosis to detect patients’ status ... -
Flavonoid and phenolic acid profiles of dehulled and whole vigna subterranea (l.) Verdc seeds commonly consumed in South Africa
(MDPI, 2022)Bambara groundnut (BGN) is an underexploited crop with a rich nutrient content and is used in traditional medicine, but limited information is available on the quantitative characterization of its flavonoids and phenolic ...