Browsing Research Articles (Biotechnology) by Title
Now showing items 31-50 of 215
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Biological synthesis of gold and silver nanoparticles using leaf extracts of Crassocephalum rubens and their comparative in vitro antioxidant activities
(Elsevier, 2020)The use of plant and plant products in the synthesis of silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs) is made possible because of the natural inherent phytochemicals responsible for the reduction of respective ... -
Biomedical Relevance of Novel Anticancer Peptides in the Sensitive Treatment of Cancer
(MDPI, 2021)The global increase in cancer mortality and economic losses necessitates the cautious quest for therapeutic agents with compensatory advantages over conventional therapies. Anticancer peptides (ACPs) are a subset of host ... -
Brown rot-type fungal decomposition of sorghum bagasse: variable success and mechanistic implications
(Hindawi Publishing Corporation, 2018)Sweet sorghum is a promising crop for a warming, drying African climate, and basic information is lacking on conversion pathways for its lignocellulosic residues (bagasse). Brown rot wood-decomposer fungi use carbohydra ... -
Building HMM and molecular docking analysis for the sensitive detection of anti-viral pneumonia antimicrobial peptides (AMPs)
(Nature Research, 2021)Pneumonia is the main reason for mortality among children under five years, causing 1.6 million deaths every year; late research has exhibited that mortality is increasing in the elderly. A few biomarkers used for its ... -
Capacity to control oxidative stress-induced caspase-like activity determines the level of tolerance to salt stress in two contrasting maize genotypes
(Springer, 2013)The response of two maize (Zea mays L.) genotypes, named GR (salt-tolerant) and SK (salt-sensitive), to salt stress (150 mM NaCl) was investigated under controlled environmental growth conditions. Genotype SK experienced ... -
Catalytic reduction of 4-nitrophenol and methylene blue by biogenic gold nanoparticles synthesized using Carpobrotus edulis fruit (sour fig) extract
(SAGE Publications, 2022)Along with the increasing requirement for efficient organic conversions using green chemistry, there is a need to develop highly efficient and eco-friendly catalytic reaction systems. Gold nanoparticles (AuNPs)-based ... -
Characterization and expression analysis of heme oxygenase genes from sorghum bicolor
(SAGE Publications, 2019)Heme oxygenases (HOs) have a major role in phytochrome chromophore biosynthesis, and chromophores in turn have antioxidant properties. Plant heme oxygenases are divided into the HO1 sub-family comprising HO1, HO3, and ... -
Characterization of a highly xylose tolerant β-xylosidase isolated from high temperature horse manure compost
(BMC, 2021): There is a continued need for improved enzymes for industry. β-xylosidases are enzymes employed in a variety of industries and although many wild-type and engineered variants have been described, enzymes that are highly ... -
Cheminformatic Characterization of Natural Antimicrob al Products for the Development of New Lead Compounds
(MDPI, 2021)The growing antimicrobial resistance (AMR) of pathogenic organisms to currently pre- scribed drugs has resulted in the failure to treat various infections caused by these superbugs. Therefore, to keep pace with the ... -
Chitosan-coated liposomes of Carissa spinarum extract: synthesis, analysis and antipneumococcal potency
(ICE Publishing, 2023)In the present study, a chitosan-coatedCarissa spinarum-polyphenol-loaded liposome (LipCsP-chitosan) nanocarrierwas fabricated for the delivery ofC. spinarumpolyphenols (CsPs) to improve the bioavailability ... -
Common bean as a potential crop for future food security: an overview of past, current and future contributions in genomics, transcriptomics, transgenics and proteomics
(Taylor & Francis Open Access, 2021)Common bean is an important legume crop having high quality protein, micronutrients, vitamins and antioxidants, which makes it a “grain of hope” for poor communities. Hence, a good number of breeding activities have been ... -
Comparative analysis of responses to field salinity stress in contrasting soybean accessions highlights NaCl exclusion in leaves as a key mechanism for salinity stress tolerance.
(JOURNAL OF OASIS AGRICULTURE AND SUSTAINABLE DEVELOPMENT, 2021)Salinity is one of the main limitations to legume productivity in many regions of the world and it is estimated that 50% of all arable land will become affected by salinity by 2050. The impact of field salinity on soybean ... -
Comparative proteomics analysis between maize and sorghum uncovers important proteins and metabolic pathways mediating drought tolerance
(MDPI, 2023)Drought severely affects crop yield and yield stability. Maize and sorghum are major crops in Africa and globally, and both are negatively impacted by drought. However, sorghum has a better ability to withstand drought ... -
Comparative venom toxin analyses of Nigerian viperidae and elapidae snakes
(Elsevier, 2023)Envenoming by snakebite is a serious health problem that maims and kills a large number of people, primarily in rural areas of developing African countries. The first comparative venom proteomic analyses of four snakes ... -
Comparative whole corona fingerprinting and protein adsorption thermodynamics of PLGA and PCL nanoparticles in human serum
(Elsevier, 2020)Nanoparticles (NPs) based on biocompatible and biodegradable polymers such as poly(lactic-co-glycolic acid) (PLGA) and polycaprolactone (PCL) represent effective systems for systemic drug delivery. Upon injection into the ... -
Computational and preclinical prediction of the antimicrobial properties of an agent isolated from monodora myristica: A novel dna gyrase inhibitor
(MDPI, 2023)The African nutmeg (Monodora myristica) is a medically useful plant. We, herein, aimed to critically examine whether bioactive compounds identified in the extracted oil of Monodora myristica could act as antimicrobial ... -
Computational insight of dexamethasone against potential targets of SARS-CoV-2
(Taylor and Francis Group, 2022)The health sector has been on the race to find a potent therapy for coronavirus disease (COVID)-19, a diseases caused by severe acute respiratory syndrome coronavirus (SARS-CoV)-2. Repurposed anti-viral drugs have played ... -
Crispr-based multi-gene integration strategies to create saccharomyces cerevisiae strains for consolidated bioprocessing
(MDPI, 2022)Significant engineering of Saccharomyces cerevisiae is required to enable consolidated bioprocessing (CBP) of lignocellulose to ethanol. Genome modification in S. cerevisiae has been successful partly due to its efficient ... -
Cross-sectional study of prevalence and determinants of uncontrolled hypertension among South African adult residents of Mkhondo municipality
(Springer Nature, 2020)Achieving the blood pressure treatment target in individuals with hypertension is a serious global health challenge. Furthermore, the actual burden of uncontrolled hypertension is poorly understood, especially in the ... -
Cross-sectional study of the association of 5 single nucleotide polymorphisms with enalapril treatment response among South African adults with hypertension
(NLM (Medline), 2021-11-19)This study investigates the association of 5 single nucleotide polymorphisms (SNPs) in selected genes (ABO, VEGFA, BDKRB2, NOS3, and ADRB2) with blood pressure (BP) response to enalapril. The study further assessed genetic ...