Browsing Research Articles (Biotechnology) by Title
Now showing items 46-65 of 219
-
Computational and preclinical prediction of the antimicrobial properties of an agent isolated from monodora myristica: A novel dna gyrase inhibitor
(MDPI, 2023)The African nutmeg (Monodora myristica) is a medically useful plant. We, herein, aimed to critically examine whether bioactive compounds identified in the extracted oil of Monodora myristica could act as antimicrobial ... -
Computational insight of dexamethasone against potential targets of SARS-CoV-2
(Taylor and Francis Group, 2022)The health sector has been on the race to find a potent therapy for coronavirus disease (COVID)-19, a diseases caused by severe acute respiratory syndrome coronavirus (SARS-CoV)-2. Repurposed anti-viral drugs have played ... -
Crispr-based multi-gene integration strategies to create saccharomyces cerevisiae strains for consolidated bioprocessing
(MDPI, 2022)Significant engineering of Saccharomyces cerevisiae is required to enable consolidated bioprocessing (CBP) of lignocellulose to ethanol. Genome modification in S. cerevisiae has been successful partly due to its efficient ... -
Cross-sectional study of prevalence and determinants of uncontrolled hypertension among South African adult residents of Mkhondo municipality
(Springer Nature, 2020)Achieving the blood pressure treatment target in individuals with hypertension is a serious global health challenge. Furthermore, the actual burden of uncontrolled hypertension is poorly understood, especially in the ... -
Cross-sectional study of the association of 5 single nucleotide polymorphisms with enalapril treatment response among South African adults with hypertension
(NLM (Medline), 2021-11-19)This study investigates the association of 5 single nucleotide polymorphisms (SNPs) in selected genes (ABO, VEGFA, BDKRB2, NOS3, and ADRB2) with blood pressure (BP) response to enalapril. The study further assessed genetic ... -
The cytotoxicity of cotyledon orbiculata aqueous extract and the biogenic silver nanoparticles derived from the extract
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)Green synthesized silver nanoparticles (AgNPs) have become popular because of their promising biological activities. However, for most of these nanoparticles, the cytotoxic effects have not been determined and their safety ... -
A decade of plant proteomics and mass spectrometry: Translation of technical advancements to food security and safety issues
(Wiley, 2013)Tremendous progress in plant proteomics driven by mass spectrometry (MS) techniques has been made since 2000 when few proteomics reports were published and plant proteomics was in its infancy. These achievements include ... -
Decoding heavy metal stress signalling in plants: Towards improved food security and safety
(MDPI, 2020)The mining of heavy metals from the environment leads to an increase in soil pollution, leading to the uptake of heavy metals into plant tissue. The build-up of toxic metals in plant cells often leads to cellular damage ... -
Degradation of hydrocarbons and heavy metal reduction by marine bacteria in highly contaminated sediments
(MDPI, 2020)Investigations on the ability of bacteria to enhance removal of hydrocarbons and reduce heavy metal toxicity in sediments are necessary to design more effective bioremediation strategies. In this study, five bacterial ... -
Design and synthesis of acyldepsipeptide-1 analogues: antibacterial activity and cytotoxicity screening
(Arabian Journal of Chemistry, 2023)Acyldepsipeptides (ADEPs) are receiving more attention as prospective antimicrobial agents due to their unique mode of action and chemical properties. However, their therapeutic potential is limited by their poor pharmacokinetic ... -
The determination of the effect(s) of solute carrier family 22‑member 2 (SLC22A2) haplotype variants on drug binding via molecular dynamic simulation systems
(Nature Research, 2022)Single nucleotide polymorphisms detected in the solute carrier member family-22 has been shown to result in a variable response in the treatment of type 2 diabetes mellitus with Metformin. This study predicted a ... -
Development of Effective Therapeutic Molecule from Natural Sources against Coronavirus Protease
(MDPI, 2021)Abstract: The SARS-CoV-2 main protease (Mpro) is one of the molecular targets for drug design. Effective vaccines have been identified as a long-term solution but the rate at which they are being administered is slow in ... -
Development of infectious transcripts and genome manipulation of black queen-cell virus of honey bees
(Microbiology Society, 2002)The South African isolate of Black queen-cell virus (BQCV), a honey bee virus, was previously found to have an 8550 nucleotide genome excluding the poly(A) tail. Its genome contained two ORFs, a 5«-proximal ORF encoding ... -
Diagnostic approaches of pneumonia for commercial-scale biomedical applications: An overview
(Taylor & Francis, 2020)Pneumonia remains the leading infectious cause of death among children under five years of age, and the elderly. Several biomarkers, which have been identified for its diagnosis lack specificity, as they could not ... -
Dietary effects of antimicrobial peptides in therapeutics
(Taylor & Francis, 2020-02-17)The notable increase in drug-resistant infections and the failure of the most potent antibiotics to establish their curative effect without side effect have presented a serious need for the discovery of new therapeutic ... -
Differentially expressed serum proteins from obese Wistar rats as a risk factor for obesity-induced diseases
(Springer Nature, 2020)Obesity is a chronic disease that negatively affects life expectancy through its association with life-threatening diseases such as cancer and cardiovascular diseases. Expression proteomics combined with in silico interaction ... -
Diversity of dsDNA viruses in a South African hot spring assessed by metagenomics and microscopy
(MDPI, 2017)The current view of virus diversity in terrestrial hot springs is limited to a few sampling sites. To expand our current understanding of hot spring viral community diversity, this study aimed to investigate the first ... -
DNA commission of the international society of forensic genetics (IGSF): recommendations on the interpretation of y-str results in forensic analysis
(Elsevier, 2020)Forensic genetic laboratories perform a large amount of STR analyses of the Y chromosome, in particular to analyze the male part of complex DNA mixtures. However, the statistical interpretation of evidence retrieved from ... -
Draft genome sequence of the putative endophytic bacterium pantoea agglomerans r6, associated with lactuca serriola from South Africa
(American Society for Microbiology, 2021)Here, we present the draft genome sequence (;4.7 Mb) of the endopyhtic bacterium Pantoea agglomerans strain R6, which was isolated from surface-sterilized roots of Lactuca serriola (prickly lettuce) -
Drought and exogenous abscisic acid alter hydrogen peroxide accumulation and diferentially regulate the expression of two maize RD22-like genes
(Nature Research, 2017)Increased biosynthesis of abscisic acid (ABA) occurs in plants in response to water defcit, which is mediated by changes in the levels of reactive oxygen species such as H2O2. Water defcit and ABA induce expression of ...