Browsing Research Articles (Biotechnology) by Issue Date
Now showing items 81-100 of 215
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Gene expression alterations and molecular analysis of CHEK1 in solid tumors
(MDPI, 2020)Alterations in the Checkpoint kinase (CHEK1) gene, its regulation, and the possible clinical outcomes in human solid tumors have not been previously examined. Therefore, the present study was carried out to evaluate the ... -
Genetic diversity, population structure and marker- trait association for 100-seed weight in international safflower panel using silicodart marker information
(MDPI, 2020)Safflower is an important oilseed crop mainly grown in the arid and semi-arid regions of the world. The aim of this study was to explore phenotypic and genetic diversity, population structure, and marker-trait association ... -
In vitro Antidiabetic and Antioxidant effects of different extracts of Catharanthus roseus and its indole alkaloid, vindoline
(MPDI, 2020)The Catharanthus roseus plant has been used traditionally to treat diabetes mellitus. Scientific evidence supporting the antidiabetic effects of this plant’s active ingredient-vindoline has not been fully evaluated. In ... -
Understanding the epidemiology, pathophysiology, diagnosis and management of SARS-CoV-2
(SAGE, 2020)The emergence of coronavirus disease 2019 (COVID-19) in December 2019 has resulted in over 20 million cases and 741,808 deaths globally, affecting more than 200 countries. COVID-19 was declared a pandemic on 11 March 2020 ... -
Socio-demographic and modifiable risk factors of diabetes and hypertension among resource constrained patients from rural areas in mdantsane township in South Africa
(Makerere University, 2020)Recently, developing countries have shown a dramatic increase in non-communicable diseases (NCDs). The burden of NCDs in South Africa has increased over the past years resulting in an estimated 37% of all-cause mortality ... -
Identification of biomarkers for the accurate and sensitive diagnosis of three bacterial pneumonia pathogens using in silico approaches
(Springer Nature, 2020): Pneumonia ranks as one of the main infectious sources of mortality among kids under 5 years of age, killing 2500 a day; late research has additionally demonstrated that mortality is higher in the elderly. A few ... -
Investigation of bioactive compounds in Crassocephalum rubens leaf and in vitro anticancer activity of its biosynthesized gold nanoparticles
(Elsevier, 2020)The development of cancer therapies has become difficult due to high metastasis, and lack of tissue selectivity, which in most cases affects normal cells. Demand for anticancer therapy is therefore increasing on daily ... -
Glucose-uptake activity and cytotoxicity of diterpenes and triterpenes isolated from lamiaceae plant species
(2020)The prevalence of diabetes mellitus (DM), considered one of the most common metabolic disorders, has dramatically increased and resulted in higher rates of morbidity and mortality around the world in the past decade. It ... -
Diagnostic approaches of pneumonia for commercial-scale biomedical applications: An overview
(Taylor & Francis, 2020)Pneumonia remains the leading infectious cause of death among children under five years of age, and the elderly. Several biomarkers, which have been identified for its diagnosis lack specificity, as they could not ... -
Differentially expressed serum proteins from obese Wistar rats as a risk factor for obesity-induced diseases
(Springer Nature, 2020)Obesity is a chronic disease that negatively affects life expectancy through its association with life-threatening diseases such as cancer and cardiovascular diseases. Expression proteomics combined with in silico interaction ... -
Applications of computational methods in biomedical breast cancer imaging diagnostics: A review
(Multidisciplinary Digital Publishing Institute (MDPI), 2020)With the exponential increase in new cases coupled with an increased mortality rate, cancer has ranked as the second most prevalent cause of death in the world. Early detection is paramount for suitable diagnosis and ... -
Degradation of hydrocarbons and heavy metal reduction by marine bacteria in highly contaminated sediments
(MDPI, 2020)Investigations on the ability of bacteria to enhance removal of hydrocarbons and reduce heavy metal toxicity in sediments are necessary to design more effective bioremediation strategies. In this study, five bacterial ... -
Inhibitory potential of repurposed drugs against the SARS-CoV-2 main protease: A computational-aided approach
(Taylor and Francis, 2020)The exponential increase in cases and mortality of coronavirus disease (COVID-19) has called for a need to develop drugs to treat this infection. Using in silico and molecular docking approaches, this study investigated ... -
Biological synthesis of gold and silver nanoparticles using leaf extracts of Crassocephalum rubens and their comparative in vitro antioxidant activities
(Elsevier, 2020)The use of plant and plant products in the synthesis of silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs) is made possible because of the natural inherent phytochemicals responsible for the reduction of respective ... -
Factors associated with glycemic control among South African adult residents of Mkhondo municipality living with diabetes mellitus
(Lippincott, Williams & Wilkins, 2020)This study examines the rate and the influencing factors of glycemic control among adult residents living with DM in Mkhondo Municipality of South Africa. In this cross-sectional study, 157 individuals attending care for ... -
Antibacterial activity of rationally designed antimicrobial peptides
(Hindawi, 2020)Many infectious diseases are still prevalent in the world’s populations since no effective treatments are available to eradicate them. e reasons may either be the antibiotic resistance towards the available therapeutic ... -
Dietary effects of antimicrobial peptides in therapeutics
(Taylor & Francis, 2020-02-17)The notable increase in drug-resistant infections and the failure of the most potent antibiotics to establish their curative effect without side effect have presented a serious need for the discovery of new therapeutic ... -
Multifunctional Gold Nanoparticles for Improved Diagnostic and Therapeutic Applications: A Review
(Springer Open, 2021)The medical properties of metals have been explored for centuries in traditional medicine for the treatment of infections and diseases and still practiced to date. Platinum-based drugs are the first class of metal-based ... -
Three Novel Bacteria Associated with Two Centric Diatom Species from the Mediterranean Sea, Thalassiosira rotula and Skeletonema marinoi
(MDPI, 2021)Diatoms are a successful group of microalgae at the base of the marine food web. For hundreds of millions of years, they have shared common habitats with bacteria, which favored the onset of interactions at different ... -
Genetic characterisation of Campylobacter concisus: Strategies for improved genomospecies discrimination
(Elsevier, 2021)Although at least two genetically distinct groups, or genomospecies, have been well documented for Campylobacter concisus, no phenotype has yet been identified for their differentiation and thus formal description as ...