Browsing Research Articles (Biotechnology) by Author "Fadaka, Adewale Oluwaseun"
Now showing items 1-15 of 15
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Anticancer and drug-sensitizing activities of gold nanoparticles synthesized from cyclopia genistoides (honeybush) extracts
Sharma, Jyoti Rajan; Sibuyi, Nicole Remaliah Samantha; Fadaka, Adewale Oluwaseun (MDPI, 2023)Synthesis of gold nanoparticles (AuNPs) using phytochemicals has become tremendously prominent in biomedical applications because of its enhanced bioactivity and biocompatibility. In this study, water extracts from the ... -
Attenuation of hyperglycemia-associated dyslipidemic, oxidative, cognitive, and inflammatory crises via modulation of neuronal ChEs/NF-κB/COX-2/NOx, and hepatorenal functional deficits by the Tridax procumbens extract
Hogan, Itam Ako; Fadaka, Adewale Oluwaseun; Kuo, Yu-Cheng (Elsevier, 2023)Tridax procumbens (cotton buttons) is a flowering plant with a medicinal reputation for treating infections, wounds, diabetes, and liver and kidney diseases. The present research was conducted to evaluate the possible ... -
Computational and preclinical prediction of the antimicrobial properties of an agent isolated from monodora myristica: A novel dna gyrase inhibitor
Onikanni, Sunday Amos; Lawal, Bashir; Fadaka, Adewale Oluwaseun; Bakare, Oluwafemi (MDPI, 2023)The African nutmeg (Monodora myristica) is a medically useful plant. We, herein, aimed to critically examine whether bioactive compounds identified in the extracted oil of Monodora myristica could act as antimicrobial ... -
Computational insight of dexamethasone against potential targets of SARS-CoV-2
Fadaka, Adewale Oluwaseun; Sibuyi, Nicole Remaliah Samantha; Madiehe, Abram Madimabe (Taylor and Francis Group, 2022)The health sector has been on the race to find a potent therapy for coronavirus disease (COVID)-19, a diseases caused by severe acute respiratory syndrome coronavirus (SARS-CoV)-2. Repurposed anti-viral drugs have played ... -
Development of Effective Therapeutic Molecule from Natural Sources against Coronavirus Protease
Fadaka, Adewale Oluwaseun; Sibuyi, Nicole Remaliah Samantha; Martin, Darius Riziki; Klein, Ashwil (MDPI, 2021)Abstract: The SARS-CoV-2 main protease (Mpro) is one of the molecular targets for drug design. Effective vaccines have been identified as a long-term solution but the rate at which they are being administered is slow in ... -
Diagnostic approaches of pneumonia for commercial-scale biomedical applications: An overview
Bakare, Olalekan Olanrewaju; Fadaka, Adewale Oluwaseun; Klein, Ashwil (Taylor & Francis, 2020)Pneumonia remains the leading infectious cause of death among children under five years of age, and the elderly. Several biomarkers, which have been identified for its diagnosis lack specificity, as they could not ... -
Dietary effects of antimicrobial peptides in therapeutics
Bakare, Olalekan Olanrewaju; Fadaka, Adewale Oluwaseun; Klein, Ashwil; Pretorius, Ashley (Taylor & Francis, 2020-02-17)The notable increase in drug-resistant infections and the failure of the most potent antibiotics to establish their curative effect without side effect have presented a serious need for the discovery of new therapeutic ... -
Functional prediction of candidate micrornas for CRC management using in silico approach
Fadaka, Adewale Oluwaseun; Pretorius, Ashley; Klein, Ashwil (MDPI, 2019)Approximately 30–50% of malignant growths can be prevented by avoiding risk factors and implementing evidence-based strategies. Colorectal cancer (CRC) accounted for the second most common cancer and the third most common ... -
Gene expression alterations and molecular analysis of CHEK1 in solid tumors
Fadaka, Adewale Oluwaseun; Bakare, Olalekan Olanrewaju; Sibuyi, Nicole Remaliah Samantha (MDPI, 2020)Alterations in the Checkpoint kinase (CHEK1) gene, its regulation, and the possible clinical outcomes in human solid tumors have not been previously examined. Therefore, the present study was carried out to evaluate the ... -
In silico identification of micrornas as candidate Colorectal cancer biomarkers
Fadaka, Adewale Oluwaseun (Sage Journals, 2019)The involvement of microRNA in cancers plays a significant role in their pathogenesis. Specific expressions of these non-coding RNAs also serve as biomarkers for early colorectal cancer diagnosis, but their laboratory/molecular ... -
Inhibitory potential of repurposed drugs against the SARS-CoV-2 main protease: A computational-aided approach
Fadaka, Adewale Oluwaseun; Aruleba, Raphael Taiwo; Sibuyi, Nicole Remaliah Samantha (Taylor and Francis, 2020)The exponential increase in cases and mortality of coronavirus disease (COVID-19) has called for a need to develop drugs to treat this infection. Using in silico and molecular docking approaches, this study investigated ... -
MicroRNA-based regulation of Aurora A kinase in breast cancer
Sibuyi, Nicole Remaliah Samantha; Fadaka, Adewale Oluwaseun; Madiehe, Abram Madimabe (Impact Journals, 2020)The involvement of non-coding RNAs (ncRNAs) in cellular physiology and disease pathogenesis is becoming increasingly relevant in recent years specifically in cancer research. Breast cancer (BC) has become a health concern ... -
Plant antimicrobial peptides (pamps): Features, applications, production, expression and challenges
Bakare, Olalekan Olanrewaju; Gokul, Arun; Fadaka, Adewale Oluwaseun (MDPI, 2022)The quest for an extraordinary array of defense strategies is imperative to reduce the challenges of microbial attacks on plants and animals. Plant antimicrobial peptides (PAMPs) are a subset of antimicrobial peptides ... -
Prospects of using gum Arabic silver nanoparticles in toothpaste to prevent dental caries
Ahmed, Omnia Abdelmoneim Khidir; Sibuyi, Nicole Remaliah Samantha; Fadaka, Adewale Oluwaseun (MDPI, 2023)There is growing interest in the use of green synthesized silver nanoparticles (AgNPs) to control and prevent dental diseases. The incorporation of green synthesized AgNPs into dentifrices to reduce pathogenic oral ... -
Understanding the epidemiology, pathophysiology, diagnosis and management of SARS-CoV-2
Sibuyi, Nicole Remaliah Samantha; Fadaka, Adewale Oluwaseun; Adewale, Olusola Bolaji (SAGE, 2020)The emergence of coronavirus disease 2019 (COVID-19) in December 2019 has resulted in over 20 million cases and 741,808 deaths globally, affecting more than 200 countries. COVID-19 was declared a pandemic on 11 March 2020 ...