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Single nucleotide polymorphisms associated with metformin and sulphonylureas’ glycaemic response among South African adults with type 2 diabetes mellitus
(MDPI, 2021)
To examine the association of polymorphisms belonging to SLC22A1, SP1, PRPF31, NBEA, SCNN1B, CPA6 and CAPN10 genes with glycaemic response to metformin and sulphonylureas (SU) combination therapy among South African adults ...
Exogenous 3,3′-diindolylmethane improves vanadium stress tolerance in brassica napus seedling shoots by modulating antioxidant enzyme activities
(MDPI, 2021)
3,3′-diindolylmethane (DIM) belongs to a family of indole glucosinolate compounds that have been shown to improve Brassica napus growth through the modulation of reactive oxygen species when applied exogenously. The B. ...
Rooibos (Aspalathus linearis) genome size estimation using flow cytometry and k-mer analyses
(MDPI, 2020)
Plant genomes provide information on biosynthetic pathways involved in the production of industrially relevant compounds. Genome size estimates are essential for the initiation of genome projects. The genome size of rooibos ...
Gold nanoparticles synthesized using extracts of cyclopia intermedia, commonly known as honeybush, amplify the cytotoxic effects of doxorubicin
(MPDI, 2021)
Cyclopia intermedia (C. intermedia) is an indigenous South African shrub used to prepare the popular medicinal honeybush (HB) tea. This plant contains high levels of mangiferin (MGF), a xanthonoid that was reported to have ...
Comparative whole corona fingerprinting and protein adsorption thermodynamics of PLGA and PCL nanoparticles in human serum
(Elsevier, 2020)
Nanoparticles (NPs) based on biocompatible and biodegradable polymers such as poly(lactic-co-glycolic acid) (PLGA) and polycaprolactone (PCL) represent effective systems for systemic drug delivery. Upon injection into the ...
Synthesis, characterization, and DNA-binding kinetics of new pd(ii) and pt(ii) thiosemicarbazone complexes: Spectral, structural, and anticancer evaluation
(Hindawi, 2020)
In a bid to come up with potential anticancer agents, a class of thiosemicarbazone ligands bearing substituted thiophene were synthesized followed by complexation with various Pd(II) and Pt(II) metal precursors. The ligands ...
PZQ Therapy: How close are we in the development of effective alternative anti-schistosomal drugs?
(Bentham Science Publishers, 2019)
Today schistosomiasis, caused mainly by the three major schistosome species (S.
mansoni, S. haematobium and S. japonicum), has for many decades and still continues to be on a
rapid and swift rise globally, claiming ...
Nodulation, leaf harvesting intensity and interval of the black-eyed bean (BEB) (Vigna unguiculata L. Walpers) cowpea type at the University of Zimbabwe, Harare, Zimbabwe
(Academic Journals, 2012)
A glasshouse pot experiment was carried out at the University of Zimbabwe, Crop Science Department in 2006 to 2007 rainy season to determine the effect of leaf harvesting intensity and interval on cowpea biological nitrogen ...
Mapping and characterisation of the sorghum cell suspension culture secretome
(Academic Journals, 2011)
Here we reported the first secretomic study of sorghum (Sorghum bicolor), a naturally drought tolerant cereal crop. In this study, we used a gel-based proteomic approach in combination with mass spectrometry to separate ...
Nitric oxide affects salt-induced changes in free amino acid levels in maize
(Elsevier, 2013)
It was assumed that salt-induced redox changes affect amino acid metabolism in maize (Zea mays L.),
and
this influence may be modified by NO. The applied NaCl treatment reduced the fresh weight of shoots
and roots. This ...