Browsing Medical Bioscience by Title
Now showing items 258-277 of 277
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The threat of aerobic vaginitis to pregnancy and neonatal morbidity
(Women's Health and Action Research Centre, 2017)Aerobic vaginitis (AV) is an endogenous opportunistic infection brought about by the disruption of the normal vaginal microbiota. Its early diagnosis and treatment during pregnancy may reduce the risk of negative pregnancy ... -
Total antioxidant capacity—Relevance, methods and clinical implications
(Blackwell Publishing Ltd, 2021)Oxidative stress is pre-empted by an adequate level of antioxidants, which scavenge oxidants when they are produced in excess by different sources, including leukocytes and immature spermatozoa. Enzymatic antioxidants, ... -
Total antioxidant capacity—Relevance, methods and clinical implications
(Blackwell Publishing Ltd, 2020)Oxidative stress is pre‐empted by an adequate level of antioxidants, which scavenge oxidants when they are produced in excess by different sources, including leukocytes and immature spermatozoa. Enzymatic antioxidants, ... -
Trends in semen parameters of infertile men in South Africa and Nigeria
(2023)There are conflicting reports on trends of semen parameters from different parts of the globe. However, in recent times there is dearth of information on the trend in Sub-Saharan countries. Therefore, in this study we ... -
Tunel assay: establishing a sperm dna fragmentation cut-off value for Egyptian infertile men
(Wiley Online Library, 2019)Male factor infertility is responsible for half of all infertility cases. Conventional semen analysis is inadequate to evaluate male fertility. Sperm DNA fragmentation (SDF) test can be done by: direct methods such as ... -
TUNEL assay—Standardized method for testing sperm DNA fragmentation
(Blackwell Publishing Ltd, 2021)Sperm DNA integrity is important for normal functions such as fertilization, implantation, pregnancy and fetal development. Sperm DNA fragmentation (SDF) is more common in infertile men and may be responsible for poor ... -
Tyrosinase and melanogenesis inhibition by indigenous African plants: A review
(Multidisciplinary Digital Publishing Institute (MDPI), 2020)The indiscriminate use of non-regulated skin lighteners among African populations has raised health concerns due to the negative effects associated with skin lightener toxicity. For this reason, there is a growing interest ... -
Understanding human coronavirus HCoV-NL63
(Bentham Science, 2010)Even though coronavirus infection of humans is not normally associated with severe diseases, the identification of the coronavirus responsible for the outbreak of severe acute respiratory syndrome showed that highly ... -
Unlocking community capabilities across health systems in low- and middle-income countries: lessons learned from research and reflective practice
(BioMed Central, 2016)The right and responsibility of communities to participate in health service delivery was enshrined in the 1978 Alma Ata declaration and continues to feature centrally in health systems debates today. Communities are a ... -
Unveiling the Inhibitory Potentials of Peptidomimetic Azanitriles and Pyridyl Esters towards SARS-CoV-2Main Protease: A MolecularModelling Investigation
(MDPI, 2023)The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for COVID-19, which was declared a global pandemic in March 2020 by the World Health Organization (WHO). Since SARS-CoV-2 main protease plays ... -
An update on the techniques used to measure oxidative stress in seminal plasma
(Blackwell Publishing Ltd, 2021)Reactive oxygen species (ROS) are produced in significant amounts by spermatozoa and leucocytes. They are necessary to carry out various physiological functions such as sperm capacitation, hyperactivation, acrosome reaction, ... -
Use of a rat ex-vivo testis culture method to assess toxicity of select known male reproductive toxicants
(Elsevier, 2016)Due to the complex physiology of the testes, in vitro models have been largely unsuccessful at modeling testicular toxicity in vivo. We conducted a pilot study to evaluate the utility of the Durand ex vivo rat seminiferous ... -
The Use of Probiotics in the Primary Prevention of Atopic Dermatitis: A Systemic Review of the Literature in Light of the Hygiene Hypothesis
(8th Conference of the Federation of African Immunological Societies, 2012)Atopic dermatitis (eczema) is a type 1 hypersensitivity reaction that is common in infants and young children, with incidence increasing in the Industrialised world. Based on epidemiological evidence, the hygiene hypothesis ... -
Utility of Antioxidants in the Treatment of Male Infertility: Clinical Guidelines Based on a Systematic Review and Analysis of Evidence
(The world journal of men's health, 2021)It is widely accepted that oxidative stress plays an important role in the pathophysiology of male infertility and that antioxidants could have a significant role in the treatment of male infertility. The main objectives ... -
Vaginal microbiomes associated with aerobic vaginitis and bacterial vaginosis
(Frontiers Media, 2018)A healthy vaginal microbiota is considered to be significant for maintaining vaginal health and preventing infections. However, certain vaginal bacterial commensal species serve an important first line of defense of the ... -
The validity and reliability of computer-aided semen analyzers in performing semen analysis: a systematic review
(AME Publishing, 2021)Infertility is defined as the inability to achieve a clinical pregnancy following one year of regular and timed intercourse without contraception (1). It is estimated that infertility affects approximately 15% of ... -
The validity and reliability of computer-aided semen analyzers in performing semen analysis: a systematic review
(Translational Andrology and Urology., 2021)Background: Computer-aided sperm analyzers (CASA) are currently used worldwide for semen analysis. However, there are doubts about their reliability to fully substitute the human operator. Therefore, this study aimed to ... -
The variable N-terminal region of DDX5 contains structural elements and auto-inhibits its interaction with NS5B of hepatitis C virus
(Portland Press, 2012)RNA helicases of the DEAD (Asp-Glu-Ala-Asp)-box family of proteins are involved in many aspects of RNA metabolism from transcription to RNA decay, but most of them have also been shown to be multifunctional. The DEAD-box ... -
Vitek characterisation of type 2 diabetes-associated Candida species
(Elsevier, 2017)Background: Type 2 diabetes mellitus (T2DM) predisposes patients to opportunistic infections, such as invasive candidiasis. Treatment of candidiasis is challenged by the emerging resistance of Candida species. In this ... -
Woman-centred care in childbirth: a concept analysis (Part 1)
(AOSIS OpenJournals, 2013)'Woman-centred care' in childbirth is a process in which a woman makes choices and is involved in and has control over her care and relationship with her midwife. The aim of this paper is to study the concept of woman-centred ...