Research Articles (Medical Bioscience): Recent submissions
Now showing items 41-60 of 258
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The effects of silver nanoparticles on RAW 264.7. Macrophages and human whole blood cell cultures
(University of the Western Cape, 2019)Silver nanoparticles (AgNPs) are commonly found in consumer products due to their antimicrobial properties. This study evaluated the effects of AgNPs on the murine macrophage cell line RAW 264.7 and human whole blood cell ... -
Exosomes form tunneling nanotubes (TUNTs) in the blood-brain barrier: A nano-anatomical perspective of barrier genesis
(Frontiers Media, 2022)The blood-brain barrier (BBB) is a robust interface between the blood and the central nervous system. Barrier type endothelium is able to limit paracellular (PC) movement, relegating molecular flux to the transendothel ... -
Morphological and physiological responses of Calobota sericea plants subjected to water limitation and subsequent rewatering
(Taylor and Francis Group, 2021)Calobota sericea is a native legume of South Africa, confined to the water-limited rangelands, and it has recently been prioritised for additional characterisation regarding its pasture potential. In this study, we examined ... -
The effects of in utero exposure to teratogens on organ size: A prospective paediatric study
(Cambridge University Press, 2021)In low-income countries, prospective data on combined effects of in utero teratogen exposure are lacking and necessitates new research. The aim of the present study was to explore the effect of in utero teratogen exposure ... -
Importance and relevance of phytochemicals present in Galenia Africana
(Hindawi, 2022)Many people in developing countries rely primarily on medicinal plants as their main source of healthcare, particularly for the treatment of skin infections. Despite the widespread use of medicinal plants, there is a lack ... -
Reply to Pallotti et al. comment on “Boitrelle et al. The sixth edition of the who manual for human semen analysis: A critical review and swot analysis. Life 2021, 11, 1368"
(MDPI, 2022)We would like to thank F. Pallotti and his colleagues for their positive comments [1] on our SWOT analysis of the strengths, weaknesses, threats and opportunities of the sixth edition of the WHO manual on semen analysis ... -
Biosynthesis of silver nanoparticles using Bersama engleriana fruits extracts and their potential inhibitory effect on resistant bacteria
(MDPI, 2022)The absence of novel, safe, and effective bactericide is an urgent concern worldwide and remains a challenge in scientific communities. The unique proprieties of silver nanoparticles (SNPs) synthesized from plant extracts ... -
The Ism between endothelial cilia and endothelial nanotubules is an evolving concept in the genesis of the BBB
(MDPI, 2022)The blood–brain barrier (BBB) is fundamental in maintaining central nervous system (CNS) homeostasis by regulating the chemical environment of the underlying brain parenchyma. Brain endothelial cells (BECs) constitute ... -
Oxidative stress and assisted reproduction: A comprehensive review of its pathophysiological role and strategies for optimizing embryo culture environment
(MDPI, 2022)Oxidative stress (OS) due to an imbalance between reactive oxygen species (ROS) and antioxidants has been established as an important factor that can negatively affect the outcomes of assisted reproductive techniques ... -
Morphometric and structural analysis of Florida manateespermatozoa
(Wiley, 2022)Sperm characteristics, such as sperm morphology and sperm morphometry areimportant in assessing sperm quality. This is especially important for the man-agement and conservation of endangered and exotic species, like the ... -
Cost of Traditional Herbal Medicines for Noncommunicable Diseases in Rural and Urban Communities in South Africa
(Elsevier Inc., 2022)Objectives: This study assessed traditional herbal medicine (THM) and conventional medicine (CM) utilization among par- participants with a noncommunicable diseases in South Africa. Methods: A cross-sectional study of the ... -
The flexible, extended coil of the pdz-binding motif of the three deadly human coronavirus e proteins plays a role in pathogenicity
(MDPI, 2022)The less virulent human (h) coronaviruses (CoVs) 229E, NL63, OC43, and HKU1 cause mild, self-limiting respiratory tract infections, while the more virulent SARS-CoV-1, MERS-CoV, and SARS-CoV-2 have caused severe outbreaks. ... -
Interventions to reduce pesticide exposure from the agricultural sector in Africa: A workshop report
(MDPI, 2022)Despite the fact that several cases of unsafe pesticide use among farmers in different parts of Africa have been documented, there is limited evidence regarding which specific interventions are effective in reducing ... -
Oxidative stress: A comprehensive review of biochemical, molecular, and genetic aspects in the pathogenesis and management of varicocele
(Korean Society for Sexual Medicine and Andrology, 2021)Sperm vitality testing is a basic semen examination that has been described in the World Health Organization (WHO) Laboratory Manual for the Examination and Processing of Human Semen from its primary edition, 40 years ago. ... -
Effect of maternal cigarette smoking and alcohol consumption during pregnancy on birth weight and cardiometabolic risk factors in infants, children and adolescents: A systematic review protocol
(BMC, 2022)Tobacco smoking and alcohol consumption during pregnancy are particularly prevalent in low socioeconomic status populations, with an adverse association with birth outcomes and cardiometabolic risk factors. However, ... -
Association among sperm chromatin condensation, sperm DNA fragmentation and 8-OHdG in seminal plasma and semen parameters in infertile men with oligoasthenoteratozoospermia
(Wiley, 2021)The present study aimed to investigate the clinical role of standard sperm diagnosis parameters (sperm concentration, motility, morphology) as well as aniline blue staining of histones, 8-OHdG, TUNEL assay were performed ... -
Polymorphisms of androgens-related genes and idiopathic male infertility in Turkish men
(Wiley, 2021)Androgens, testosterone and dihydrotestosterone (DHT) are endocrine regulators of spermatogenesis and act via androgen receptor (AR). The aim of this study was to investigate the association(s) of AR (CAG repeat length), ... -
Characterization and Toxicity of Hypoxoside Capped Silver Nanoparticles
(MDPI, 2022)The reducing potential of plant extracts in the green synthesis of nanoparticles has been associated with their phytochemicals. Although pharmacologically inactive, a norlignan diglucoside “hypoxoside” (HP) occurs in large ... -
Data Management Plans in the genomics research revolution of Africa: Challenges and Recommendations
(Elsevier, 2021)Drafting and writing a data management plan (DMP) is increasingly seen as a key part of the academic research process. A DMP is a document that describes how a researcher will collect, document, describe, share, and preserve ... -
Functional landscape of SARS-CoV-2 cellular restriction
(Cell Press, 2021)A deficient interferon (IFN) response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been implicated as a determinant of severe coronavirus disease 2019 (COVID-19). To identify the molecular ...