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Now showing items 71-79 of 79
Prediction of human-Bacillus anthracis protein–protein interactions using multi-layer neural network
(Oxford University Press, 2018)
Triplet amino acids have successfully been included in feature selection to predict
human-HPV protein-protein interactions (PPI). The utility of supervised learning methods is
curtailed due to experimental data not being ...
Human coronavirus OC43 3CL protease and the potential of ML188 as a broad-spectrum lead compound: Homology modelling and molecular dynamic studies
(Springer Nature, 2015)
The coronavirus 3 chymotrypsin-like protease (3CLpro) is a validated target in the design of potential
anticoronavirus inhibitors. The high degree of homology within the protease’s active site and substrate conservation
supports ...
Understanding biobanking : An assessment of the public engagement speaking book intervention Biobanking and Me
(South African Medical Association, 2019)
Meaningful engagement with donors of biological samples intended for human-sample biobanking increases knowledge, and allows donors to make informed decisions. Informed donors provide a platform for public awareness, ...
Prioritization of anti-malarial hits from nature: Chemo-informatic profiling of natural products with in vitro antiplasmodial activities and currently registered anti-malarial drugs
(BMC, 2016)
A large number of natural products have shown in vitro antiplasmodial activities. Early identification
and prioritization of these natural products with potential for novel mechanism of action, desirable pharmacokinetics ...
Modelling human protein interaction networks as metric spaces has potential in disease research and drug target discovery
(BMC, 2014)
We have recently shown by formally modelling human protein interaction networks (PINs) as metric
spaces and classified proteins into zones based on their distance from the topological centre that hub proteins are
primarily ...
Semantic interrogation of a multi knowledge domain ontological model of tendinopathy identifies four strong candidate risk genes
(Nature Research, 2016)
Tendinopathy is a multifactorial syndrome characterised by tendon pain and thickening, and impaired
performance during activity. Candidate gene association studies have identified genetic factors
that contribute to ...
RAMICS: Trainable, high-speed and biologically relevant alignment of high-throughput sequencing reads to coding DNA
(Oxford University Press, 2014)
The challenge presented by high-throughput sequencing necessitates the development of novel
tools for accurate alignment of reads to reference sequences. Current approaches focus on using heuristics to map reads quickly ...
Computational characterization of iron metabolism in the tsetse disease vector, glossina morsitans: Ire stem-loops
(BMC, 2016)
Iron metabolism and regulation is an indispensable part of species survival, most importantly for
blood feeding insects. Iron regulatory proteins are central regulators of iron homeostasis, whose binding to iron
response ...
Exploring new genetic variants within col5a1 intron 4‐exon 5 region and tgf‐β family with risk of anterior cruciate ligament ruptures
(Wiley, 2020)
Variants within genes encoding structural and regulatory elements of ligaments have
been associated with musculoskeletal soft tissue injury risk. The role of intron 4‐exon
5 variants within the α1 chain of type V collagen ...