Browsing Research Articles (School of Pharmacy) by Title
Now showing items 95-114 of 151
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Nanomedicines for infectious diseases
(Springer Nature, 2019)Infectious diseases continue to pose a significant threat to global health. Over 200 infectious diseases are currently known to man. Fortunately, only a handful are responsible for significant morbidity and mortality. ... -
Nevirapine plasma concentrations in premature infants exposed to single-dose nevirapine for prevention of mother-tochild transmission of HIV-1
(Health and Medical Publishing Group, 2011)Background: No pharmacokinetic data exist for premature infants receiving single-dose nevirapine (sd NVP) for prevention of mother-to-child transmission (MTCT) of HIV. Aim: To describe NVP decay pharmacokinetics in two ... -
New palladium (II) complexes from halogen substituted Schiff base ligands: Synthesis, spectroscopic, biological activity, density functional theory, and molecular docking investigations
(Inorganica Chimica Acta, 2023)Two novel palladium (II) complexes Pd(L1)2 and Pd(L2)2 derived from ON donor bidentate ligands: 2-(((2-bromo-4-chlorophenyl)imino)methyl)phenol (HL1) and 2-(((-bromo-4-methylphenyl)imino)methyl)phenol (HL2) are reported. ... -
Novel South African rare actinomycete kribbella speibonae Strain SK5: A prolific producer of hydroxamate siderophores including new dehydroxylated congeners
(MDPI, 2020)In this paper, we report on the chemistry of the rare South African Actinomycete Kribbella speibonae strain SK5, a prolific producer of hydroxamate siderophores and their congeners. Two new analogues, dehydroxylated ... -
Parental reporting of adverse drug reactions in South Africa: An online survey
(AOSIS, 2021)The high incidence of adverse drug reactions (ADRs) in children is of global concern. Enhancing the reporting of ADRs could contribute to making safer medicines available to children.To assess parents’ awareness of ... -
Patient with Kaposi’s Sarcoma: Teaching students medicine management therapy
(Medpharm, 2018)Interprofessional education (IPE) is a cornerstone in advancing health professional education, with the aim of improving the overall quality of healthcare.1 The World Health Organization (WHO) states: “Interprofessional ... -
Pharmaceutical co-crystal: An alternative strategy for enhanced physicochemical properties and drug synergy
(Wiley Open Access, 2020)A growing number of co-crystals in the literature are proof of how significant the co-crystallization concept has become. Co-crystallization enhances physicochemical properties through the formation of intermolecular ... -
A pharmacist-led prospective antibiotic stewardship intervention improves compliance to community-acquired pneumonia guidelines in 39 public and private hospitals across South Africa
(Elsevier, 2020)Introduction: Pharmacists in low-middle-income countries (LMIC) are few and lack antibiotic stewardship (AS) training. The ability was assessed of non-specialised pharmacists to implement stewardship interventions and ... -
Pharmacists’ approach to optimise safe medication use in paediatric patients
(MPDI, 2021)Paediatric patients are unique, yet challenging patients to care for by pharmacists. Paediatric medicine use requires special consideration. Pharmacists play an important role in educating and counselling patients, carers, ... -
Pharmacokinetics of vancomycin in critically Ill children: A systematic review
(European journal of drug metabolism and pharmacokinetics, 2021)Background and Objective Vancomycin is often used in the ICU for the treatment of Gram-positive bacterial infection. In critically ill children, there are pathophysiologic changes that afect the pharmacokinetics of vancomycin. ... -
Physicochemical stability of enriched phenolic fractions of cyclopia genistoides and ex vivo bi-directional permeability of major xanthones and benzophenones
(Georg Thieme Verlag, 2021)Fractions of an ultrafiltered Cyclopia genistoides extract, respectively enriched in xanthones and benzophenones, were previously shown to inhibit mammalian α -glucosidase in vitro. The present study investigated ex vivo ... -
Phytochemical components and GC–MS analysis of Petiveria alliaceae L. fractions and volatile oils
(De Gruyter, 2023)Phytochemical constituents are important in the determination of plant activities. Their presence in medicinal plants gives their therapeutic values. These phytoconstituents possesses pharmacological activities that include ... -
A pilot study to test psychophonetics methodology for self-care and empathy in compassion fatique, burnout and secondary traumatic stress
(AOSIS OpenJournals, 2013)Background: Home-based care is recognised as being a stressful occupation. Practitioners working with patients experiencing high levels of trauma may be susceptible to compassion fatigue, with the sustained need to remain ... -
Polymer-based protein delivery systems for loco-regional administration
(Taylor and Francis Group, 2021)With the advent of recombinant technology, a wide variety of biocompatible therapeutic proteins can be produced with relative ease. These proteins are formulated and subsequently administered in patients to treat various ... -
A post-market quality assessment of first-line, fixed-dose combination antiretrovirals in South Africa
(Journal of Applied Pharmaceutical Science, 2019)South Africa has the world’s largest antiretroviral (ARV) program and despite having stringent upstream medicine’s regulatory oversight, the post-market reassessment of ARV quality is prohibitively resource intensive. The ... -
Potential beneficial effects of Tulbaghia violacea William Henry Harvey (Alliaceae) on cardiovascular system - A review
(Pharmacotherapy Group, University of Benin, 2015)Tulbaghia violacea William Henry Harvey (Harv. Alliaceae) is a small bulbous herb belonging to the family Alliaceae. It is used in South Africa to treat fever, colds, asthma, paralysis, and hypertension. Meanwhile, ... -
Preceptor reflections on the Community Health clinical rotation for fourth year pharmacy students at the University of the Western Cape
(2019)This paper describes the community health clinic rotation of the Patient Care Experience programme (PaCE) offered to fourth year pharmacy students (2018) at the University of the Western Cape. Reflections from the collective ... -
Preparation and evaluation of pralidoxime-loaded plga nanoparticles as potential carriers of the drug across the blood brain barrier
(Hindawi, 2015)Pralidoxime is an organophosphate antidote with poor central nervous system distribution due to a high polarity. In the present study, pralidoxime-loaded poly(lactic-co-glycolic acid) nanoparticles were prepared and ... -
Proprotein convertase subtilisin/kexin type 9 genetic screening using the vervet (Chlorocebus aethiops) model
(Journal of Medical Primatology, 2022)Background: The proprotein convertase subtilisin/kexin type 9 (PCSK9) gene has come to prominence due to its reported function in the clearance of low-density li-poprotein cholesterol. The vervet monkey (Chlorocebus ... -
Provision of syndromic treatment of sexually transmitted infections by community pharmacists: a potentially underutilized HIV prevention strategy
(Lippincott, Williams & Wilkins, 2003)Background: Sexually transmitted infections (STIs) are known risk factors for HIV infection. Goal: The goal of this study was to assess the current and potential future role that community pharmacists in Western Cape, South ...