Biotechnology: Recent submissions
Now showing items 161-180 of 219
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Antibacterial activity of biogenic silver and gold nanoparticles synthesized from Salvia africana-lutea and Sutherlandia frutescens
(Nanotechnology, 2020)Nanoparticles (NPs) synthesized using various chemical and physical methods are often cytotoxic which restricts their use in biomedical applications. In contrast, metallic biogenic NPs synthesized using biological systems ... -
Genetic characterisation of Campylobacter concisus: Strategies for improved genomospecies discrimination
(Elsevier, 2021)Although at least two genetically distinct groups, or genomospecies, have been well documented for Campylobacter concisus, no phenotype has yet been identified for their differentiation and thus formal description as ... -
Synthesis, characterization, and DNA-binding kinetics of new pd(ii) and pt(ii) thiosemicarbazone complexes: Spectral, structural, and anticancer evaluation
(Hindawi, 2020)In a bid to come up with potential anticancer agents, a class of thiosemicarbazone ligands bearing substituted thiophene were synthesized followed by complexation with various Pd(II) and Pt(II) metal precursors. The ligands ... -
Comparative whole corona fingerprinting and protein adsorption thermodynamics of PLGA and PCL nanoparticles in human serum
(Elsevier, 2020)Nanoparticles (NPs) based on biocompatible and biodegradable polymers such as poly(lactic-co-glycolic acid) (PLGA) and polycaprolactone (PCL) represent effective systems for systemic drug delivery. Upon injection into the ... -
Gold nanoparticles synthesized using extracts of cyclopia intermedia, commonly known as honeybush, amplify the cytotoxic effects of doxorubicin
(MPDI, 2021)Cyclopia intermedia (C. intermedia) is an indigenous South African shrub used to prepare the popular medicinal honeybush (HB) tea. This plant contains high levels of mangiferin (MGF), a xanthonoid that was reported to have ... -
Rooibos (Aspalathus linearis) genome size estimation using flow cytometry and k-mer analyses
(MDPI, 2020)Plant genomes provide information on biosynthetic pathways involved in the production of industrially relevant compounds. Genome size estimates are essential for the initiation of genome projects. The genome size of rooibos ... -
Genetic diversity, population structure and marker- trait association for 100-seed weight in international safflower panel using silicodart marker information
(MDPI, 2020)Safflower is an important oilseed crop mainly grown in the arid and semi-arid regions of the world. The aim of this study was to explore phenotypic and genetic diversity, population structure, and marker-trait association ... -
Decoding heavy metal stress signalling in plants: Towards improved food security and safety
(MDPI, 2020)The mining of heavy metals from the environment leads to an increase in soil pollution, leading to the uptake of heavy metals into plant tissue. The build-up of toxic metals in plant cells often leads to cellular damage ... -
Gene expression alterations and molecular analysis of CHEK1 in solid tumors
(MDPI, 2020)Alterations in the Checkpoint kinase (CHEK1) gene, its regulation, and the possible clinical outcomes in human solid tumors have not been previously examined. Therefore, the present study was carried out to evaluate the ... -
Socio-demographic and modifiable risk factors of diabetes and hypertension among resource constrained patients from rural areas in mdantsane township in South Africa
(Makerere University, 2020)Recently, developing countries have shown a dramatic increase in non-communicable diseases (NCDs). The burden of NCDs in South Africa has increased over the past years resulting in an estimated 37% of all-cause mortality ... -
Understanding the epidemiology, pathophysiology, diagnosis and management of SARS-CoV-2
(SAGE, 2020)The emergence of coronavirus disease 2019 (COVID-19) in December 2019 has resulted in over 20 million cases and 741,808 deaths globally, affecting more than 200 countries. COVID-19 was declared a pandemic on 11 March 2020 ... -
Antibacterial activity of rationally designed antimicrobial peptides.
(Hindawi, 2020)Many infectious diseases are still prevalent in the world’s populations since no effective treatments are available to eradicate them. e reasons may either be the antibiotic resistance towards the available therapeutic ... -
Cross-sectional study of prevalence and determinants of uncontrolled hypertension among South African adult residents of Mkhondo municipality
(Springer Nature, 2020)Achieving the blood pressure treatment target in individuals with hypertension is a serious global health challenge. Furthermore, the actual burden of uncontrolled hypertension is poorly understood, especially in the ... -
DNA commission of the international society of forensic genetics (IGSF): recommendations on the interpretation of y-str results in forensic analysis
(Elsevier, 2020)Forensic genetic laboratories perform a large amount of STR analyses of the Y chromosome, in particular to analyze the male part of complex DNA mixtures. However, the statistical interpretation of evidence retrieved from ... -
Predicting haplogroups using a versatile machine learning program (PredYMaLe) on a new mutationally balanced 32 Y-STR multiplex (CombYplex): Unlocking the full potential of the human STR mutation rate spectrum to estimate forensic parameters
(Elsevier, 2020)We developed a new mutationally well-balanced 32 Y-STR multiplex (CombYplex) together with a machine learning (ML) program PredYMaLe to assess the impact of STR mutability on haplogourp prediction, while respecting forensic ... -
Ethical publication of research on genetics and genomics of biological material: guidelines and recommendations
(Elsevier, 2020)Forensic Science International: Genetics and Forensic Science International: Reports communicate research on a variety of biological materials using genetics and genomic methods. Numerous guidelines have been produced to ... -
Apoptosis in cancer cells is induced by alternative splicing of hnrnpa2/b1 through splicing of bcl-x, a mechanism that can be stimulated by an extract of the South African medicinal plant, cotyledon orbiculata
(Frontiers Media S.A., 2020)Alternative splicing is deregulated in cancer and alternatively spliced products can be linked to cancer hallmarks. Targeting alternative splicing could offer novel effective cancer treatments. We investigated the effects ... -
MicroRNA-based regulation of Aurora A kinase in breast cancer
(Impact Journals, 2020)The involvement of non-coding RNAs (ncRNAs) in cellular physiology and disease pathogenesis is becoming increasingly relevant in recent years specifically in cancer research. Breast cancer (BC) has become a health concern ... -
Genomic association of single nucleotide polymorphisms with blood pressure response to hydrochlorothiazide among south african adults with hypertension
(MDPI, 2020): This study described single nucleotide polymorphisms (SNPs) in hydrochlorothiazideassociated genes and further assessed their correlation with blood pressure control among South African adults living with hypertension. ... -
Degradation of hydrocarbons and heavy metal reduction by marine bacteria in highly contaminated sediments
(MDPI, 2020)Investigations on the ability of bacteria to enhance removal of hydrocarbons and reduce heavy metal toxicity in sediments are necessary to design more effective bioremediation strategies. In this study, five bacterial ...