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HIV-1 diversity and the implementation of integrase strand-transfer inhibitors as part of combination antiretroviral therapy
(SAMA, 2020)
: The integrase (IN) strand-transfer inhibitor (InSTI)
dolutegravir (DTG) is now recommended by the World Health
Organization as part of salvage and/or first-line combination
antiretroviral therapy (cART).[1] DTG has a ...
Structural rearrangements maintain the Glycan Shield of an HIV-1 envelope trimer after the loss of a glycan
(Nature Research, 2018)
The HIV-1 envelope (Env) glycoprotein is the primary target of the humoral immune response and a
critical vaccine candidate. However, Env is densely glycosylated and thereby substantially protected
from neutralisation. ...
Predictive classifier models built from natural products with antimalarial bioactivity using machine learning approach
(Public Library of Science, 2018)
In view of the vast number of natural products with potential antiplasmodial bioactivity
and cost of conducting antiplasmodial bioactivity assays, it may be judicious to learn from
previous antiplasmodial bioassays and ...
Structure based identification of novel inhibitors against ATP synthase of Mycobacterium tuberculosis: A combined in silico and in vitro study
(International Journal of Biological Macromolecules, 2019)
The shortcomings of conventional tuberculosis treatments resulting from the development of drug resistance in
Mycobacteriumtuberculosis drive a need for the formulation of novel therapeutic agents. The diarylquinoline ...
Designing novel possible kinase inhibitor derivatives as therapeutics against Mycobacterium tuberculosis: An in silico study
(Scientific Reports, 2019)
Rv2984 is one of the polyphosphate kinases present in Mycobacterium tuberculosis involved in the
catalytic synthesis of inorganic polyphosphate, which plays an essential role in bacterial virulence
and drug resistance. ...
Developing reproducible bioinformatics analysis workflows for heterogeneous computing environments to support African genomics
(Springer Nature, 2018)
Background: The Pan-African bioinformatics network, H3ABioNet, comprises 27 research institutions in 17 African
countries. H3ABioNet is part of the Human Health and Heredity in Africa program (H3Africa), an African-led ...
Trends in Genotypic HIV-1 Antiretroviral resistance between 2006 and 2012 in South African Patients receiving first- and second line antiretroviral treatment regimensTrends in Genotypic HIV-1 Antiretroviral resistance between 2006 and 2012 in South African Patients receiving first- and second line antiretroviral treatment regimens
(University of the Western CapePublic Library of Science -- PLoS, 2013)
South Africa's national antiretroviral (ARV) treatment program expanded in 2010 to include the nucleoside
reverse transcriptase (RT) inhibitors (NRTI) tenofovir (TDF) for adults and abacavir (ABC) for children. We ...
Designing a course model for distance-based online bioinformatics training in Africa: the H3ABioNet experience
(Public Library of Science, 2017)
Africa is not unique in its need for basic bioinformatics training for individuals from a diverse
range of academic backgrounds. However, particular logistical challenges in Africa, most
notably access to bioinformatics ...
Exome sequencing identifies novel dysferlin mutation in a family with pauci-symptomatic heterozygous carriers
(Springer Nature, 2018)
Background: We investigated a South African family of admixed ancestry in which the first generation (G1) developed
insidious progressive distal to proximal weakness in their twenties, while their offspring (G2) experienced ...
Exome sequencing identifies novel dysferlin mutation in a family with paucisymptomatic heterozygous carriers
(BioMed Central, 2018)
BACKGROUND: We investigated a South African family of admixed ancestry in which the first generation (G1) developed
insidious progressive distal to proximal weakness in their twenties, while their offspring (G2) experienced ...